BAB Bs200Pro / Bs200Doc İle Yapılan  Bazı Yayınlar

• Yayın: Solution Cross-Linked Poly(isobutylene) Gels: Synthesis and Swelling Behavior

  • Oguz Okay,†,‡ Selda Durmaz,† and Burak Erman*,§
    TUBITAK Marmara Research Center, Department of Chemistry, P.O. Box 21, 41420 Gebze,
    Kocaeli, Turkey, Istanbul Technical University, Department of Chemistry, 80626 Maslak, Istanbul,
    Turkey, and Sabanci University, Faculty of Engineering and Natural Sciences, Orhanli, 81474 Tuzla,
    Istanbul, Turkey
    Received February 22, 2000; Revised Manuscript Received April 24, 2000

• Yayın: Neuroprotective Effect of Erythropoietin on Hypoxic-Ischemic Brain Injury in Neonatal Rats

  • Abdullah Kumral a Erdener Ozer b Osman Yilmaz c Mustafa Akhisaroglu d
    Necati Gokmen e Nuray Duman a Cagnur Ulukus b Sermin Genc f
    Hasan Ozkana
    Departments of aPediatrics, bPathology, cExperimental Animal Laboratory, dPhysiology,
    eAnesthesiology and Reanimation, and fMedical Biology and Genetics, School of Medicine, Dokuz Eylul University,
    Izmir, Turkey

• Yayın: Cyclosporine A Toxicity in Association With Reduced Renal Mass

  • M. Gü ray, S. Sarıoğlu, M. Türkmen, O. Yılmaz, H. Ellidokuz, A. Gelal, H. Işlekel, A. Çoker, and E. Özer

• Yayın: Positive End-expiratory Pressure Reduces Pneumocephalus in Spinal Intradural Tumor Surgery

Abstract:
We tested the hypothesis that 5 cm H2O of positive end-expiratory pressure (PEEP) reduces the incidence of pneumocephalus in patients who undergo spinal intradural tumor surgery. Fifty-three ASA I to III patients who underwent thoracolumbar intradural tumor surgery between the years 2003 and 2006 were included in this study. All patients received propofol, fentanyl, and cisatracurium for induction of the anesthesia. Maintenance was provided by propofol infusion and, oxygen (50%) and air (50%). Group I (n=28) did not receive PEEP whereas group II (n=25) received PEEP as 5 cm H2O. Cranial computerized tomography was taken at 8 hours after the surgery and cases were evaluated for pneumocephalus using BAB Bs200ProP Image System software. Pneumocephalus areas between 0.03 and 4.24 cm2 were observed in 9 patients, 8 in group I and 1 patient in group II at the 8th postoperative hour, at various localizations. There were no neurologic findings in other patients except for 2 patients in group I who presented with headache and mental status change. Although the cerebrospinal fluid leakage is minimal, N2O is not used and the patients are well hydrated, pneumocephalus with neurologic deficits may occur in patients undergoing microsurgical spinal intradural tumor surgery in prone position. In our study, we showed that using 5 cm H2O PEEP perioperatively reduced the risk of pneumocephalus. However, more cases must be studied to support this hypothesis.

(C) 2007 Lippincott Williams & Wilkins, Inc.

• Yayın: Interaction with intraocular lens materials: Does heavy silicone oil act like silicone oil?

Aylin Yaman, MD, A. Osman Saatci, MD, Sulen Sarıog˘lu, MD, F. Hakan O¨ ner, MD, Ismet Durak, MD

PURPOSE: To determine the interaction of heavy silicone oil with various intraocular lens (IOL) materials and whether heavy silicone oil covers the silicone IOL optic as silicone oil does. SETTING: Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey. METHODS: The study group comprised 5 poly(methyl methacrylate) (PMMA) IOLs, 4 foldable silicone IOLs, 5 foldable hydrophilic acrylic IOLs, and 5 foldable hydrophobic acrylic IOLs. Each IOL was bathed in balanced salt solution (BSS) for 10 minutes and then placed in heavy silicone oil dyed with Sudan Black for another 10 minutes. Afterward, each IOL was reimmersed in BSS for 5 minutes and examined under the light microscope. Digital images were analyzed to determine the optic area covered with heavy silicone oil.

To cite this article: Mehmet Atilla Türkmen, Salih Kavukçu, Sülen Sarıolu, Alper Soylu, Hülya Akhunlar, Osman Yılmaz, Hülya Güven (2006)
Effects of lactational cyclosporine A use on rat pups
Pediatric Transplantation 10 (4), 454–460.
doi:10.1111/j.1399-3046.2006.00495.x

Abstract
Abstract: We aimed to evaluate the structural and functional changes in the thymus and kidneys of rat pups whose mothers were given cyclosporine A (CsA) during lactational period. Six adult nursing Wistar rats and their 30 pups were studied. Rat pups were divided into four groups as follows: 21-day treated group and 21-day placebo group, each including 10 breastfeeding pups sacrificed on the 21st day, whose mothers were given CsA or placebo, respectively (infancy groups) and, 60-day treated group and 60-day placebo group, each including five breastfeeding pups sacrificed on the 60th day, whose mothers were given CsA or placebo, respectively (puberty groups). While CsA levels of mother rats were very high, CsA levels of 21-day treated group pups were zero. There were no renal histomorphometric differences between study and control pups in both age groups. Renal function parameters showed significant differences between study and control pups in the infancy group: the 21-day treated group pups had significantly lower urine volume, proteinuria, FENa and urinary NAG/creatinine ratio. GFR was also lower in the 21-day treated group, but the difference was not significant, and serum creatinine levels were also not different. Renal function differences were not present among the pubertal pups. Thymic corticomedullary ratio of the 21-day treated group was significantly higher than the 21-day placebo group, while there was no difference between the 60-day treated group and 60-day placebo group. There were no significant changes in the number and distribution of CD3+, CD4+, and CD8+ thymocytes between study and control pups in both age groups. In conclusion, breastfeeding by CsA-treated mother rats induced structural alterations in the thymus and functional changes in the kidneys of the rat pups during infancy. Disturbances in the kidneys and thymus mostly improved after CsA exposure was over